Insulin-like Growth Factor 1 Signaling Axis Meets p53 Genome Protection Pathways
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چکیده
منابع مشابه
Insulin-like Growth Factor 1 Signaling Axis Meets p53 Genome Protection Pathways
Clinical, epidemiological, and experimental evidence indicate that the insulin-like growth factors (IGFs) are important mediators in the biochemical chain of events that lead from a phenotypically normal to a neoplastic cell. The IGF1 receptor (IGF1R), which mediates the biological actions of IGF1 and IGF2, exhibits potent pro-survival and antiapoptotic activities. The IGF1R is highly expressed...
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ژورنال
عنوان ژورنال: Frontiers in Oncology
سال: 2016
ISSN: 2234-943X
DOI: 10.3389/fonc.2016.00159